Detalhe da pesquisa
1.
Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism.
Proc Natl Acad Sci U S A
; 121(7): e2315069121, 2024 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38315851
2.
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 560(7717): 192-197, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046105
3.
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 619(7970): E48, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37402863
4.
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.
PLoS Pathog
; 16(11): e1008932, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33141865
5.
Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform.
Hum Reprod
; 37(3): 466-475, 2022 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35048946
6.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc Natl Acad Sci U S A
; 116(19): 9318-9323, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962368
7.
Preparation, biological & cheminformatics-based assessment of N2,N4-diphenylpyrimidine-2,4-diamine as potential Kinase-targeted antimalarials.
Bioorg Med Chem
; 46: 116348, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34479064
8.
A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market.
Molecules
; 26(5)2021 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33807614
9.
Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.
PLoS Pathog
; 14(2): e1006850, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29425238
10.
The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.
Chembiochem
; 19(5): 425-429, 2018 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29226533
11.
Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania.
PLoS Pathog
; 12(11): e1005971, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27812217
12.
2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas' disease.
Bioorg Med Chem Lett
; 28(18): 3025-3030, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30104093
13.
Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1.
Bioorg Med Chem Lett
; 28(19): 3255-3259, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30143424
14.
Automated design of ligands to polypharmacological profiles.
Nature
; 492(7428): 215-20, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23235874
15.
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Nature
; 464(7289): 728-32, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20360736
16.
C-reactive protein is essential for innate resistance to pneumococcal infection.
Immunology
; 142(3): 414-20, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24673624
17.
In vitro and in vivo studies of trypanocidal activity of dietary isothiocyanates.
Planta Med
; 80(2-3): 183-6, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24452460
18.
Sperm Toolbox-A selection of small molecules to study human spermatozoa.
PLoS One
; 19(2): e0297666, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38377053
19.
The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.
Antimicrob Agents Chemother
; 57(10): 4699-706, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856774
20.
Bespoke Drug Discovery Training for Low-Middle Income Countries.
ACS Med Chem Lett
; 14(8): 1014-1016, 2023 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37583828